![]() The laser diffraction instrument applied by Particle Analytical (Malvern Mastersizer 30) has a flow-through cell for dispersion of particles in liquid media or a dry dispenser for dispersion of particles in the air. Particle Analytical can determine these refractive index parameters. The use of Mie theory presupposes knowledge of the light refractive index of the particles and the dispersion media and the imaginary part of the refractive index of the particles. The laser diffraction pattern is measured and correlated to the particle size distribution based on Fraunhofer or Mie theory. The diffraction light pattern (He-Ne & Krypton laser) is dependent on the particle size. The laser passes through the dispersion media and is diffracted by the particles. The sample is dispersed in either air or a suitable liquid media. Instrument and measuring principle, laser diffractionīy laser diffraction analysis, it is possible to measure particles sizes between 0. Control the content uniformity of formulations, especially for the low drug load formulations.The PSD will always be the utmost critical attribute for the dry powder inhalation (DPI) products.Detection of agglomerates and study the strength of agglomerates.Investigation of PSD stability during shelf life.Investigate the effect of PSD on dissolution and bioavailability. ![]() Study if the PSD is a critical quality attribute for the manufacturing process.Test the influence of production changes on the particles.The particle size distribution measured by laser diffraction is helpful for: Laser diffraction is used for the determination of particle size distribution (PSD). Critical Quality Attributes and Specifications.Differential Scanning Calorimetry (DSC).
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